Germline deletion of Rgs2 and/or Rgs5 in male mice does not exacerbate left ventricular remodeling induced by subchronic isoproterenol infusion

Germline deletion of Rgs2 and/or Rgs5 in male mice does not exacerbate left ventricular remodeling induced by subchronic isoproterenol infusion

Abstract Sympathoexcitation is a hallmark of heart failure, with sustained β‐adrenergic receptor (βAR)‐G protein signaling activation. βAR signaling is modulated by regulator of G protein signaling (RGS) proteins. Previously, we reported that Gαi/o regulation by RGS2 or RGS5 is key to ventricular rh...

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Bibliographic Details
Main Authors: Shelby Dahlen, Ipsita Mohanty, Bo Sun, Sanjana Nallapaneni, Patrick Osei‐Owusu
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Physiological Reports
Subjects:
adrenergic receptors
cardiac physiology
cardiomyopathy
G protein signaling
RGS
Online Access:https://doi.org/10.14814/phy2.70178
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https://doi.org/10.14814/phy2.70178

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