The mechanism of enterogenous toxin methylmalonic acid aggravating calcium-phosphorus metabolic disorder in uremic rats by regulating the Wnt/β-catenin pathway

The mechanism of enterogenous toxin methylmalonic acid aggravating calcium-phosphorus metabolic disorder in uremic rats by regulating the Wnt/β-catenin pathway

Abstract Background Uremia (UR) is caused by increased UR-related toxins in the bloodstream. We explored the mechanism of enterogenous toxin methylmalonic acid (MMA) in calcium-phosphorus metabolic disorder in UR rats via the Wnt/β-catenin pathway. Methods The UR rat model was established by 5/6 nep...

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Bibliographic Details
Main Authors:	Xing Fan, Jing Li, Yan Gao, Lin Li, Haisong Zhang, Zhaoyu Bi
Format:	Article
Language:	English
Published:	BMC 2025-01-01
Series:	Molecular Medicine
Subjects:	Enterogenous toxin methylmalonic acid Uremia Wnt/β-catenin pathway Intestinal flora imbalance Fecal metabolomics Intestinal permeability
Online Access:	https://doi.org/10.1186/s10020-025-01067-y
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