Oral versus long-acting injectable antipsychotic in first episode schizophrenia: A 12 weeks interventional study
Background: There is underutilization of long-acting injectable (LAI) antipsychotics for first-episode schizophrenia (FES) despite having convenient dosing and treatment retention. LAIs are predominantly used for patients with poor compliance, chronic course, and multiple relapses. Materials and Met...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-04-01
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| Series: | Indian Journal of Psychiatry |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_389_22 |
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| _version_ | 1832593599203639296 |
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| author | Ramandeep Kaur Ajeet Sidana Nidhi Malhotra Shikha Tyagi |
| author_facet | Ramandeep Kaur Ajeet Sidana Nidhi Malhotra Shikha Tyagi |
| author_sort | Ramandeep Kaur |
| collection | DOAJ |
| description | Background:
There is underutilization of long-acting injectable (LAI) antipsychotics for first-episode schizophrenia (FES) despite having convenient dosing and treatment retention. LAIs are predominantly used for patients with poor compliance, chronic course, and multiple relapses.
Materials and Methods:
Seventy-two treatment naïve patients with the first episode of Schizophrenia (DSM-5) were assessed for baseline severity of psychopathology using the positive and negative syndrome scale (PANSS) and quality of life (QOL) using the WHOQOL-BREF scale. Patients were randomized to receive either oral haloperidol or LAI haloperidol for a period of 12 weeks.
Results:
Both the groups had a significant reduction in PANSS scores and improvement in QoL over 12 weeks period (P = 0.0001). The LAI group showed greater adherence and significantly better quality of life than the oral group (P = 0.023). The mean numbers of side effects were less in the LAI group at week 2 as compared to the oral group.
Conclusion:
LAI haloperidol is similar to oral haloperidol in patients with FES with respect to treatment response and offers benefits in form of a lesser number of side effects during early treatment, overall better adherence rates, and better QOL. |
| format | Article |
| id | doaj-art-23f063b49b5a44cbbc2a21d5b75117ba |
| institution | Kabale University |
| issn | 0019-5545 1998-3794 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Psychiatry |
| spelling | doaj-art-23f063b49b5a44cbbc2a21d5b75117ba2025-01-20T11:14:26ZengWolters Kluwer Medknow PublicationsIndian Journal of Psychiatry0019-55451998-37942023-04-0165440441110.4103/indianjpsychiatry.indianjpsychiatry_389_22Oral versus long-acting injectable antipsychotic in first episode schizophrenia: A 12 weeks interventional studyRamandeep KaurAjeet SidanaNidhi MalhotraShikha TyagiBackground: There is underutilization of long-acting injectable (LAI) antipsychotics for first-episode schizophrenia (FES) despite having convenient dosing and treatment retention. LAIs are predominantly used for patients with poor compliance, chronic course, and multiple relapses. Materials and Methods: Seventy-two treatment naïve patients with the first episode of Schizophrenia (DSM-5) were assessed for baseline severity of psychopathology using the positive and negative syndrome scale (PANSS) and quality of life (QOL) using the WHOQOL-BREF scale. Patients were randomized to receive either oral haloperidol or LAI haloperidol for a period of 12 weeks. Results: Both the groups had a significant reduction in PANSS scores and improvement in QoL over 12 weeks period (P = 0.0001). The LAI group showed greater adherence and significantly better quality of life than the oral group (P = 0.023). The mean numbers of side effects were less in the LAI group at week 2 as compared to the oral group. Conclusion: LAI haloperidol is similar to oral haloperidol in patients with FES with respect to treatment response and offers benefits in form of a lesser number of side effects during early treatment, overall better adherence rates, and better QOL.https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_389_22adherenceantipsychoticfesfirst-episode schizophrenialaiquality of life |
| spellingShingle | Ramandeep Kaur Ajeet Sidana Nidhi Malhotra Shikha Tyagi Oral versus long-acting injectable antipsychotic in first episode schizophrenia: A 12 weeks interventional study Indian Journal of Psychiatry adherence antipsychotic fes first-episode schizophrenia lai quality of life |
| title | Oral versus long-acting injectable antipsychotic in first episode schizophrenia: A 12 weeks interventional study |
| title_full | Oral versus long-acting injectable antipsychotic in first episode schizophrenia: A 12 weeks interventional study |
| title_fullStr | Oral versus long-acting injectable antipsychotic in first episode schizophrenia: A 12 weeks interventional study |
| title_full_unstemmed | Oral versus long-acting injectable antipsychotic in first episode schizophrenia: A 12 weeks interventional study |
| title_short | Oral versus long-acting injectable antipsychotic in first episode schizophrenia: A 12 weeks interventional study |
| title_sort | oral versus long acting injectable antipsychotic in first episode schizophrenia a 12 weeks interventional study |
| topic | adherence antipsychotic fes first-episode schizophrenia lai quality of life |
| url | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_389_22 |
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