Generation and evaluation of a novel PI3K-targeting gene therapy in the failing mouse heart and healthy sheep heart

Generation and evaluation of a novel PI3K-targeting gene therapy in the failing mouse heart and healthy sheep heart

Heart failure (HF) remains a clinical challenge with cardiac dysfunction typically progressing even with treatment, and heart transplants only available to small numbers. We previously identified phosphoinositide 3-kinase (PI3K, p110α) as a master regulator of exercise-induced cardioprotection, and...

Full description

Saved in:
Bibliographic Details
Main Authors: Sebastian Bass-Stringer, Daniel G. Donner, Clive N. May, Aya Matsumoto, Emma I. Masterman, Aascha A. D'Elia, Yi Ching Chen, Helen Kiriazis, Jieting Luo, Roger Chooi, Clara Liu Chung Ming, Paul Gregorevic, Colleen J. Thomas, Bianca C. Bernardo, Kate L. Weeks, Julie R. McMullen
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Journal of Molecular and Cellular Cardiology Plus
Subjects:
Heart failure
AAV
PI3K
Gene therapy
Mouse
Large animal
Online Access:http://www.sciencedirect.com/science/article/pii/S2772976125001977
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S2772976125001977

Similar Items