Rat embryonic stem cell-based in vitro testing platform for mammalian embryo toxicology at pre- and post-implantation stages

IntroductionThe international guidelines outlining the mandatory developmental toxicology studies of new molecules on pre-implantation, post-implantation and organogenesis phases, require a minimum of 60 pregnant female rats for each molecule to be tested. To date, available in vitro methods still h...

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Bibliographic Details
Main Authors: Corinne Quadalti, Marzia Moretti, Fabio Ferrazzi, Laura Calzà, Luciana Giardino, Vito Antonio Baldassarro
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Toxicology
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Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2025.1561386/full
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