Combining the DNA methylation markers of circulating tumor cells with immune infiltrating cells to assess recurrence and prognosis and to suggest a therapeutic strategy in stage III-IV colorectal cancer

Combining the DNA methylation markers of circulating tumor cells with immune infiltrating cells to assess recurrence and prognosis and to suggest a therapeutic strategy in stage III-IV colorectal cancer

IntroductionCirculating tumor DNA (ctDNA) methylation markers show potential for early detection of cancer metastasis. This study aimed to identify ctDNA methylation markers predictive of recurrence and prognosis in colorectal cancer (CRC) patients, and to explore the influence of the tumor immune m...

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Bibliographic Details
Main Authors: Juan Zhou, Danli Ye, Yuansen Li, Xuwen Lai, Wenzhi Cui, Wenyuan He, Ling Yu, Jingyi Wu, Guangning Yan, Chengyong Lei, Wei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
ctDNA methylation
CRC
prognosis prediction
tumor immune microenvironment
ZNF671
ZNF132
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1607548/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1607548/full

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