A highly sensitive quantitative method of polysialic acid reveals its unique changes in brain aging and neuropsychiatric disorders

A highly sensitive quantitative method of polysialic acid reveals its unique changes in brain aging and neuropsychiatric disorders

Abstract Polysialic acid (polySia), a glycoepitope critical for neural development and plasticity, remains difficult to quantify owing to its structural complexity. Here, we present a highly sensitive sandwich enzyme-linked immunosorbent assay (ELISA) utilizing novel probes to measure polySia expres...

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Main Authors: Masaya Hane, Ayane Naramura, Kaito Hayakawa, Chikara Abe, Takahiro Nakagawa, Itaru Kushima, Soma Furukawa, Yuki Fukami, Keisuke Ikegami, Kazumasa Saigoh, Susumu Kusunoki, Masahisa Katsuno, Norio Ozaki, Ken Kitajima, Chihiro Sato
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-02583-x
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https://doi.org/10.1038/s41598-025-02583-x

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