Self-assembled PROTACs enable protein degradation to reprogram the tumor microenvironment for synergistically enhanced colorectal cancer immunotherapy

Self-assembled PROTACs enable protein degradation to reprogram the tumor microenvironment for synergistically enhanced colorectal cancer immunotherapy

Both β-catenin and STAT3 drive colorectal cancer (CRC) growth, progression, and immune evasion, and their co-overexpression is strongly associated with a poor prognosis. However, current small molecule inhibitors have limited efficacy due to the reciprocal feedback activation between STAT3 and β-cat...

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Bibliographic Details
Main Authors: Xinchen Lu, Jinmei Jin, Ye Wu, Jiayi Lin, Xiaokun Zhang, Shengxin Lu, Jiyuan Zhang, Chunling Zhang, Maomao Ren, Hongzhuan Chen, Weidong Zhang, Xin Luan
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-01-01
Series:Bioactive Materials
Subjects:
STAT3
β-catenin
NP-PROTACs
Immunosuppressive microenvironment
Colorectal cancer therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X24004171
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