Beta-blockers prolong response to androgen deprivation therapy in prostate cancer through modulation of the neuro-immuno-oncology axis

Beta-blockers prolong response to androgen deprivation therapy in prostate cancer through modulation of the neuro-immuno-oncology axis

Abstract Background The therapeutic impact of beta-blockers (BB), beta-adrenergic receptor antagonists, on prostate cancer remains controversial. The underlying health conditions of BB users complicate the ability to isolate and evaluate the specific effects of these drugs on the tumour cells. This...

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Main Authors: Malin Hagberg Thulin, Håkon Ramberg, Heidi Kristin Nielsen, Helene Hartvedt Grytli, Shivanthe Sivanesan, Abhilash D. Pandya, Kotryna Seip, Kjetil Wessel Andressen, Anna Linder, Miriam Øijordsbakken, Matti Poutanen, Betina Katz, Bente Halvorsen, Gunhild Mari Mælandsmo, Kristin Austlid Taskén
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Translational Medicine
Subjects:
Castration-resistant prostate cancer
Beta-adrenergic receptor
Oxidative phosphorylation
Androgen receptor
PI3K/AKT/mTOR
SRC
Online Access:https://doi.org/10.1186/s12967-025-06644-7
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https://doi.org/10.1186/s12967-025-06644-7

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