Single-cell transcriptomic analysis identified resistant MDSCs and a stress-tolerant gene co-expression network as common MDSC features across multiple disease settings

Single-cell transcriptomic analysis identified resistant MDSCs and a stress-tolerant gene co-expression network as common MDSC features across multiple disease settings

BackgroundMyeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immunosuppressive myeloid cells. The identification of a molecular signature common to MDSC regardless of tissue source would aid in the classification of cells as MDSCs.MethodsSingle-cell RNA sequencing (scRNA-seq)...

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Bibliographic Details
Main Authors: Tianmeng Chen, Julia Hughes, Alyssa Gregory, Julia Conroy, Patricia Loughran, Jinming Song, Wei Chen, Timothy Billiar
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
myeloid derived suppressor cells
MDSCs
cellular stress
scRNA-seq
stress tolerant
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1565211/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1565211/full

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