The Nrf2-HMOX1 pathway as a therapeutic target for reversing cisplatin resistance in non-small cell lung cancer via inhibiting ferroptosis

The Nrf2-HMOX1 pathway as a therapeutic target for reversing cisplatin resistance in non-small cell lung cancer via inhibiting ferroptosis

Abstract Cisplatin resistance is a major cause of poor prognosis in non-small cell lung cancer (NSCLC). Cisplatin-induced lung cancer cell death is associated with ferroptosis, a type of recently identified programmed cell death. Nrf2 is a critical component of the antioxidant system, and its protum...

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Main Authors: Ling Zuo, Xinru Zou, Jia Ge, Shuning Hu, Yixuan Fang, Yi Xu, Rui Chen, Sheng Xu, Guangyang Yu, Xiaorong Zhou, Lili Ji
Format: Article
Language:English
Published: Nature Publishing Group 2025-06-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02564-z
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https://doi.org/10.1038/s41420-025-02564-z

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