A ROS-responsive, aptamer-targeted graphene oxide nanocomposite for site-specific glutathione release in cerebral ischemia-reperfusion injury

A ROS-responsive, aptamer-targeted graphene oxide nanocomposite for site-specific glutathione release in cerebral ischemia-reperfusion injury

Cerebral ischemia-reperfusion (I/R) injury is a major contributor to mortality and long-term disability worldwide, primarily due to excessive reactive oxygen species (ROS) generation after blood flow is restored. Although current treatments focus on reestablishing perfusion, they offer limited prote...

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Bibliographic Details
Main Authors: Meiying Li, Lili Wei, Wenxu Liu, Jiawen Wang, Qiujie Lu, Xianjue Chen, Lee Yong Lim, Jingxin Mo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
glutathione
cerebral ischemia-reperfusion injury
graphene oxide
oxidative stress
fibrinogen aptamer
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1543870/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1543870/full

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