Syk inhibitors reduce tau protein phosphorylation and oligomerization

Syk inhibitors reduce tau protein phosphorylation and oligomerization

Spleen tyrosine kinase (Syk), a non-receptor-type tyrosine kinase, has a wide range of physiological functions. A possible role of Syk in Alzheimer's disease (AD) has been proposed. We evaluated the localization of Syk in the brains of patients with AD and control participants. Human neuroblast...

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Main Authors: Tomohisa Yamaguchi, Tadanori Hamano, Kiyonao Sada, Rei Asano, Nicholas M. Kanaan, Hirohito Sasaki, Shu-Hui Yen, Yuki Kitazaki, Yoshinori Endo, Soichi Enomoto, Norimichi Shirafuji, Masamichi Ikawa, Osamu Yamamura, Youshi Fujita, Koji Aoki, Hironobu Naiki, Maho Morishima, Yuko Saito, Shigeo Murayama, Yasunari Nakamoto
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Syk
Tau
Phosphorylation
Autophagy
Caspase 3
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124002560
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http://www.sciencedirect.com/science/article/pii/S0969996124002560

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