Targeting PTBP3‐Mediated Alternative Splicing of COX11 Induces Cuproptosis for Inhibiting Gastric Cancer Peritoneal Metastasis

Targeting PTBP3‐Mediated Alternative Splicing of COX11 Induces Cuproptosis for Inhibiting Gastric Cancer Peritoneal Metastasis

Abstract Numerous aberrant splicing events are implicated in tumor progression, yet comprehensive reports on splicing factors and events associated with peritoneal metastasis in gastric cancer (GCPM) are lacking. In this study, PTBP3 is found to be significantly overexpressed in peritoneal metastati...

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Bibliographic Details
Main Authors: Yajing Zhou, Chao Dong, Xiaochun Shen, Pengbo Wang, Tao Chen, Weikang Li, Xiaotong Sun, Peiyuan Li, Chengxiang Xu, Kaipeng Duan, Dongbao Li, Jin Zhou
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Advanced Science
Subjects:
alternative splicing
antisense oligonucleotide drugs
cuproptosis
gastric cancer peritoneal metastasis
patient‐derived organoids‐based xenograft
Online Access:https://doi.org/10.1002/advs.202415983
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https://doi.org/10.1002/advs.202415983

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