Clusterin-mediated polarization of M2 macrophages: a mechanism of temozolomide resistance in glioblastoma stem cells

Clusterin-mediated polarization of M2 macrophages: a mechanism of temozolomide resistance in glioblastoma stem cells

Abstract Glioblastoma remains one of the most lethal malignancies, largely due to its resistance to standard chemotherapy such as temozolomide. This study investigates a novel resistance mechanism involving glioblastoma stem cells (GSCs) and the polarization of M2-type macrophages, mediated by the e...

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Bibliographic Details
Main Authors: Jianping Wen, Xia Wu, Zhicheng Shu, Dongxu Wu, Zonghua Yin, Minglong Chen, Kun Luo, Kebo Liu, Yulong Shen, Yi Le, Qingxia Shu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Stem Cell Research & Therapy
Subjects:
Glioblastoma
Tumor stem cells
Macrophage polarization
Clusterin
Drug resistance
Online Access:https://doi.org/10.1186/s13287-025-04247-z
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https://doi.org/10.1186/s13287-025-04247-z

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