Do Perineuronal Nets Stabilize the Engram of a Synaptic Circuit?

Do Perineuronal Nets Stabilize the Engram of a Synaptic Circuit?

Perineuronal nets (PNNs), a specialized form of extra cellular matrix (ECM), surround numerous neurons in the CNS and allow synaptic connectivity through holes in its structure. We hypothesize that PNNs serve as gatekeepers that guard and protect synaptic territory and thus may stabilize an engram c...

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Bibliographic Details
Main Authors: Varda Lev-Ram, Sakina Palida Lemieux, Thomas J. Deerinck, Eric A. Bushong, Alex J. Perez, Denise R. Pritchard, Brandon H. Toyama, Sung Kyu R. Park, Daniel B. McClatchy, Jeffrey N. Savas, Michael Whitney, Stephen R. Adams, Mark H. Ellisman, John Yates, Roger Y. Tsien
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Cells
Subjects:
perineuronal nets
life-long-memory
fear conditioning
SILAM
SBEM
Online Access:https://www.mdpi.com/2073-4409/13/19/1627
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