Intravenous mesenchymal stem cell transplantation mitigates pulmonary vascular remodeling but poses dose related risks in a pulmonary veno-occlusive disease model

Intravenous mesenchymal stem cell transplantation mitigates pulmonary vascular remodeling but poses dose related risks in a pulmonary veno-occlusive disease model

Abstract Background Pulmonary veno-occlusive disease (PVOD) is a rare subtype of disease that causes pulmonary hypertension with vascular involvement of postcapillary structures of pulmonary vasculature. The disease has a poor prognosis with no effective therapy. The study aimed to determine whether...

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Bibliographic Details
Main Authors: Junko Katagiri, Jun Homma, Ryo Takagi, Hidekazu Sekine, Takeshi Shinkawa, Hiroshi Niinami, Tatsuya Shimizu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Stem Cell Research & Therapy
Subjects:
Pulmonary veno-occlusive disease
Pulmonary hypertension
Mesenchymal stem cells
Cell therapy
Vascular remodeling
Adverse event
Online Access:https://doi.org/10.1186/s13287-025-04400-8
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https://doi.org/10.1186/s13287-025-04400-8

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