AQP4 Aggravates Cognitive Impairment in Sepsis‐Associated Encephalopathy through Inhibiting Nav1.6‐Mediated Astrocyte Autophagy

AQP4 Aggravates Cognitive Impairment in Sepsis‐Associated Encephalopathy through Inhibiting Nav1.6‐Mediated Astrocyte Autophagy

Abstract The pathology of sepsis‐associated encephalopathy (SAE) is related to astrocyte‐inflammation associated with aquaporin‐4 (AQP4). The aim here is to investigate the effects of AQP4 associated with SAE and reveal its underlying mechanism causing cognitive impairment. The in vivo experimental...

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Main Authors: Dan‐Dan Zhu, Yue‐Lin Huang, Song‐Yu Guo, Na Li, Xue‐Wei Yang, Ao‐Ran Sui, Qiong Wu, Yue Zhang, Yue Kong, Qi‐Fa Li, Ting Zhang, Wen‐Fei Zheng, Ai‐Ping Li, Jian Yu, Tong‐Hui Ma, Shao Li
Format: Article
Language:English
Published: Wiley 2023-05-01
Series:Advanced Science
Subjects:
AQP4
astrocyte
autophagy
neuroinflammation
sepsis‐associated encephalopathy
sodium channel Nav1.6
Online Access:https://doi.org/10.1002/advs.202205862
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https://doi.org/10.1002/advs.202205862

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