Nonbilayer Phospholipid Arrangements Are Toll-Like Receptor-2/6 and TLR-4 Agonists and Trigger Inflammation in a Mouse Model Resembling Human Lupus

Nonbilayer Phospholipid Arrangements Are Toll-Like Receptor-2/6 and TLR-4 Agonists and Trigger Inflammation in a Mouse Model Resembling Human Lupus

Systemic lupus erythematosus is characterized by dysregulated activation of T and B cells and autoantibodies to nuclear antigens and, in some cases, lipid antigens. Liposomes with nonbilayer phospholipid arrangements induce a disease resembling human lupus in mice, including IgM and IgG antibodies a...

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Main Authors: Carlos Wong-Baeza, Alonso Tescucano, Horacio Astudillo, Albany Reséndiz, Carla Landa, Luis España, Jeanet Serafín-López, Iris Estrada-García, Sergio Estrada-Parra, Leopoldo Flores-Romo, Carlos Wong, Isabel Baeza
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:Journal of Immunology Research
Online Access:http://dx.doi.org/10.1155/2015/369462
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http://dx.doi.org/10.1155/2015/369462

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