The translational inhibitor 4EBP/Thor is required for Drosophila adaptation to hypoxia

Abstract Adaptation to hypoxia requires the activation of concerted cellular mechanisms mainly dependent on the transcription factor HIF/Sima. 4E-BP/Thor is a CAP-dependent translation inhibitor involved in several cellular and developmental processes, which has been previously shown to be required...

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Bibliographic Details
Main Authors: Eleonora Sorianello, Maximiliano J. Katz, Julieta M. Acevedo, Mariana Melani, Joel I. Perez-Perri, Pablo Wappner
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-94457-5
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