Cell-free DNA next-generation sequencing for Mycobacterium tuberculosis obtained from plasma of children with active tuberculosis

Cell-free DNA next-generation sequencing for Mycobacterium tuberculosis obtained from plasma of children with active tuberculosis

Abstract Background Difficulties in microbiologically confirming childhood tuberculosis (TB) can result in delayed treatment and increased disease severity. Methods In this study, we for the first time used whole genome next-generation sequencing (NGS) to detect cell-free DNA (cfDNA) from Mycobacter...

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Main Authors: Shuting Quan, Xue Tian, Yuting Sun, Hui Qi, Weiwei Jiao, Baixu Sun, Fang Xu, Min Fang, Xuemei Yang, Xi Zeng, Kun Duan, Jichao Wang, Xue Fu, Li Duan, Lin Sun, Adong Shen
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Pediatrics
Subjects:
Next-generation sequencing
Cell-free DNA
Tuberculosis
Child
Diagnosis
Online Access:https://doi.org/10.1186/s12887-025-05526-7
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https://doi.org/10.1186/s12887-025-05526-7

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