Study protocol of the multicentre, randomised, triple-blind, placebo-controlled MERCURI-2 trial: promoting effective renoprotection in cardiac surgery patients by inhibition of sodium glucose cotransporter (SGLT)-2

Study protocol of the multicentre, randomised, triple-blind, placebo-controlled MERCURI-2 trial: promoting effective renoprotection in cardiac surgery patients by inhibition of sodium glucose cotransporter (SGLT)-2

Introduction Acute kidney injury (AKI) is a major complication after cardiac surgery and is associated with postoperative morbidity and mortality. Currently, no effective therapy exists to reduce the incidence of postoperative AKI. Sodium-glucose cotransporter-2 (SGLT2) inhibitors are effective in r...

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Main Authors: Frederique Paulus, Daniël H van Raalte, Alexander PJ Vlaar, Thomas GV Cherpanath, Abraham H Hulst, Bas M Gerritse, Thierry V Scohy, Benedikt Preckel, Jeroen Hermanides, Marcel G Dijkgraaf, Denise P Veelo, Eline F Bruggemans, Susanne Eberl, Maaike SY Thio, Ayla Y Stobbe, Maartina Oosterom-Eijmael, Nelson P Monteiro de Oliveira, Ed D Niesten, Martijn Tolsma, Ferdinand TF Snellen, T Rettig, M B Godfried, Magiel F Voogd, Jeroen Wink, Lisa MM van der Werff, Robert JM Klautz, Marcella CA Müller, Rients N de Boer, Jorinde AW Polderman, Catherine SC Bouman, Lars IP Snel, Abby Roest, Cato Schmitz, Giel Cox, Hajar Taârnit, Imran Uddin, Lars G Knaap, Merlijn Reijrink, Naomi Chen, Divya PR Tika, Nathalie J Huizing, Tahira El Benhaji, Youri Schut, Michelle Verhagen, Alice C Pap, Yvonne J Jordens, Henrico JFT Wesselink
Format: Article
Language:English
Published: BMJ Publishing Group 2025-05-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/5/e095504.full
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