Who should be included in first-in-human trials? A systematic review of reasons

Abstract Background First-in-human trials mark a significant turning point in translational research, with novel therapies being tested in humans for the first time. Who should be included in FIH trials is a topic of ongoing debate amongst researchers, clinicians, ethicists, and sponsors. Yet, no co...

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Bibliographic Details
Main Authors: Lieke van Kempen, Martine C. de Vries, Eelco J. P. de Koning, Nienke de Graeff
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Translational Medicine
Subjects:
Online Access:https://doi.org/10.1186/s12967-025-06550-y
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