GRSF1 loss in THP-1 macrophages promotes senescence-associated transcription in neighboring fibroblasts

GRSF1 loss in THP-1 macrophages promotes senescence-associated transcription in neighboring fibroblasts

Abstract Immunosenescence, the age-associated decline in immune function, is accompanied by altered macrophage phenotypes and increased chronic inflammation. Here, we examined the role of the mitochondrial RNA-binding protein GRSF1 in regulating macrophage-driven inflammation and its impact on neigh...

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Main Authors: Younggi Lee, Seokwoo Jo, Mi-Hee Lim, Sangik Hwang, Sohyeon Jang, Kyuseok Kim, Sung-Jin Yoon, Jian Sima, M. Laura Idda, Kyoung Mi Kim, Myriam Gorospe, Chungoo Park, Ji Heon Noh
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
GRSF1
THP-1 macrophages
Cell senescence
Online Access:https://doi.org/10.1038/s41598-025-11385-0
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https://doi.org/10.1038/s41598-025-11385-0

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