Dual Functions of Androgen Receptor Overexpression in Triple-Negative Breast Cancer: A Complex Prognostic Marker

Dual Functions of Androgen Receptor Overexpression in Triple-Negative Breast Cancer: A Complex Prognostic Marker

A subset of triple-negative breast cancer (TNBC) expresses the androgen receptor (AR), but thresholds for AR positivity and its clinical significance vary. We hypothesize that objective assessment outperforms subjective methods, and that high AR negatively impacts prognosis. In a population-based TN...

Full description

Saved in:

Bibliographic Details
Main Authors:	Umay Kiraz, Emma Rewcastle, Silja K. Fykse, Ingrid Lundal, Einar G. Gudlaugsson, Ivar Skaland, Håvard Søiland, Jan P. A. Baak, Emiel A. M. Janssen
Format:	Article
Language:	English
Published:	MDPI AG 2025-01-01
Series:	Bioengineering
Subjects:	triple-negative breast neoplasm androgen receptor tumor-infiltrating lymphocytes fibrotic focus biomarkers
Online Access:	https://www.mdpi.com/2306-5354/12/1/54
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Androgen receptor overexpression by immunohistochemistry in malignant salivary gland tumors in Tanzania
by: Subira Matiku, et al.
Published: (2025-01-01)

Community pharmacy’s role in dispensing androgens and supporting harm reduction amid current policy dilemmas
by: Timothy Piatkowski, et al.
Published: (2025-01-01)

Health Implications of Anabolic-Androgenic Steroids: Usage, Risks, and Treatment Approaches - The Literature Review
by: Krzysztof Jodłowski, et al.
Published: (2025-02-01)

Comparing the Prognostic Value of PTEN and Akt Expression with the Mitotic Activity Index in Adjuvant Chemotherapy-Treated Node-Negative Breast Cancer patients aged <55 years
by: Emiel A. M. Janssen, et al.
Published: (2007-01-01)

Estimated prevalence and incidence of hypersensitivity pneumonitis in Japan
by: Tsukasa Okamoto, et al.
Published: (2025-01-01)

An Overview of the Deadly Effects of Anabolic-Androgenic Steroids: Clinical Cases and Scientific Insights
by: Maciej Mossakowski, et al.
Published: (2025-01-01)

Use of Anabolic-Androgenic Steroids and Male Fertility: A Systematic Review and Meta-analysis
by: Prashant Motiram Mulawkar, et al.
Published: (2023-10-01)

Relationship between androgen receptor and androgen receptor-related protein expression in breast cancers focusing on morphologically identified carcinoma with apocrine differentiation
by: Haruto Nishida, et al.
Published: (2025-01-01)

Cell-specific functions of androgen receptor in skeletal muscles
by: Hiroshi Sakai, et al.
Published: (2024-05-01)

In silico and in vitro evaluation of potential agonistic and antagonistic estrogenic and androgenic activities of pure cyanotoxins, microcystin-LR and cylindrospermopsin
by: Antonio Casas-Rodríguez, et al.
Published: (2025-01-01)

Androgenic response of Triticum durum-Dasypyrum villosum amphidiploids and their parental forms
by: H. Stoyanov, et al.
Published: (2022-04-01)

Secondary Cancer after Androgen Deprivation Therapy in Prostate Cancer: A Nationwide Study
by: Jae Heon Kim, et al.
Published: (2025-01-01)

Mathematical modeling of continuous and intermittent androgen suppression for the treatment of advanced prostate cancer
by: Alacia M. Voth, et al.
Published: (2017-05-01)

Androgen receptor dynamics in prostate cancer: from disease progression to treatment resistance
by: Caihong Li, et al.
Published: (2025-02-01)

Fibrosis in PCLS: comparing TGF-β and fibrotic cocktail
by: Carlos Machahua, et al.
Published: (2025-01-01)

Cancer-associated fibroblasts promote pro-tumor functions of neutrophils in pancreatic cancer via IL-8: potential suppression by pirfenidone
by: Tomohiko Yagi, et al.
Published: (2025-02-01)

Interrelation of Natural Polyphenol and Fibrosis in Diabetic Nephropathy
by: Ye Ma, et al.
Published: (2024-12-01)

Androgen deprivation therapy use and the risk of heart failure in patients with prostate cancer: a systematic review and meta-analysis
by: Amir Alinejad Khorram, et al.
Published: (2024-12-01)

Linear analysis of micromorphic thermoelastic materials with microtemperatures and triple porosity
by: Kansal Tarun
Published: (2024-01-01)

A Case–Control Study of the Association of Novel Androgens (11-KT and DHT), Classical Androgens (Testosterone and DHEAS), Hormones (LH, FSH, 17-OHP, Insulin, and SHBG), Insulin Resistance (HOMA-IR), and Dyslipidemia in Polycystic Ovarian Syndrome (PCOS)
by: Nirmal Kumar, et al.
Published: (2025-01-01)

Does Baseline Serum Androgen Levels Have an Impact on Ovulation Induction Cycle Outcomes by Using Clomifene Citrate among Infertile Women with Polycystic Ovary Syndrome? A Retrospective Cohort Study
by: Serkan Kahyaoglu, et al.
Published: (2023-08-01)

Androgenic Anabolic Steroids Cause Thiol Imbalance in the Vascular Endothelial Cells
by: Halszka Ponamarczuk, et al.
Published: (2025-01-01)

Exploring therapeutic strategies for androgen-independent prostate cancer using a magnetic coculture platform
by: Anjani Chavali, et al.
Published: (2025-06-01)

A more accurate relationship between serum androgen and metabolism among healthy, nonobese, reproductive-age women based on liquid chromatography-tandem mass spectrometry
by: Sha Ye, et al.
Published: (2024-01-01)

Effectiveness of autologous growth factor concentrates combined with topical minoxidil in patients of androgenic alopecia
by: Lavanya Maripati, et al.
Published: (2025-01-01)

Treatment-related Hypertension as a Prognostic Factor for De Novo Metastatic Hormone-sensitive Prostate Cancer: A Retrospective Real-world Evidence Study
by: Giuseppe Salfi, et al.
Published: (2025-01-01)

Ovarian Sclerosing Stromal Tumour Associated with Hirsutism in an Adolescent
by: Mehmet Dolanbay, et al.
Published: (2014-12-01)

Development of Novel Nomograms to Predict 5- and 7-Year Biochemical-Recurrence-Free Survival in High-Risk Prostate Cancer Patients After Carbon-Ion Radiotherapy and Androgen Deprivation Therapy
by: Takanobu Utsumi, et al.
Published: (2025-01-01)

Major adverse cardiovascular events among Black and White Veterans receiving androgen deprivation therapy for prostate cancer: a retrospective cohort study
by: Alexander R. Lucas, et al.
Published: (2025-02-01)

A Simulated Model of a Triple Band Patch Antenna Proposed for Vital Signs Monitoring Equipment
by: Anfal Shukur Taher, et al.
Published: (2023-09-01)

METHODOLOGICAL APPROACHES TO DEVELOPMENT REGIONAL INTERACTION CENTER «GOVERNMENT-BUSINESS-SCIENCE» IN THE CONTEXT OF «TRIPLE HELIX» MODEL
by: V. Mikhaylov
Published: (2016-10-01)

Knowledge triple extraction in cybersecurity with adversarial active learning
by: Tao LI, et al.
Published: (2020-10-01)

STAFFING MECHANISM TRIPLE HELIX
by: L. Artamonova, et al.
Published: (2016-06-01)

Triple-attentions based salient object detector for strip steel surface defects
by: Li Zhang, et al.
Published: (2025-01-01)

Global scenario of silica-associated diseases: A review on emerging pathophysiology of silicosis and potential therapeutic regimes
by: Prasad Sherekar, et al.
Published: (2025-06-01)

Single-cell RNA-seq reveals immune cell heterogeneity and increased Th17 cells in human fibrotic skin diseases
by: Cheng-Cheng Deng, et al.
Published: (2025-01-01)

Effect of Basal Testosterone and Dehydroepiandrosterone Sulphate Levels on in Vitro Fertilization Outcome in Normoresponders
by: İnci Kahyaoğlu, et al.
Published: (2013-12-01)

Network pharmacological analysis and in vitro testing of the rutin effects on triple-negative breast cancer
by: Chang Cheng, et al.
Published: (2025-01-01)

RSL3 induces ferroptosis by activating the NF-κB signalling pathway to enhance the chemosensitivity of triple-negative breast cancer cells to paclitaxel
by: Jialin Yuan, et al.
Published: (2025-01-01)

The correlation between the expression of androgen receptor splice variant-7 (AR-V7) protein with the time of occurrence of castration-resistant prostate cancer and overall survival in prostate cancer in Indonesian population
by: Indrawarman Soerohardjo, et al.
Published: (2025-02-01)