Dual Functions of Androgen Receptor Overexpression in Triple-Negative Breast Cancer: A Complex Prognostic Marker

Dual Functions of Androgen Receptor Overexpression in Triple-Negative Breast Cancer: A Complex Prognostic Marker

A subset of triple-negative breast cancer (TNBC) expresses the androgen receptor (AR), but thresholds for AR positivity and its clinical significance vary. We hypothesize that objective assessment outperforms subjective methods, and that high AR negatively impacts prognosis. In a population-based TN...

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Bibliographic Details
Main Authors: Umay Kiraz, Emma Rewcastle, Silja K. Fykse, Ingrid Lundal, Einar G. Gudlaugsson, Ivar Skaland, Håvard Søiland, Jan P. A. Baak, Emiel A. M. Janssen
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Bioengineering
Subjects:
triple-negative breast neoplasm
androgen receptor
tumor-infiltrating lymphocytes
fibrotic focus
biomarkers
Online Access:https://www.mdpi.com/2306-5354/12/1/54
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