Shear stress-triggered adenosine triphosphate regulates angiogenic properties of human periodontal ligament stem cells

Shear stress-triggered adenosine triphosphate regulates angiogenic properties of human periodontal ligament stem cells

Abstract Mechanical forces stimulate human periodontal ligament stem cells (HPDLSCs) to release extracellular adenosine triphosphate (eATP). The eATP impacts various functions of HPDLSCs, i.e., immunosuppression and inflammation. eATP has been reported to promote the angiogenesis of pulmonary vascul...

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Main Authors: Maythwe Kyawsoewin, Jeeranan Manokawinchoke, Chutimon Termkwanchareon, Hnin Yu Lwin, Sanicha Yaklai, Nuttapol Limjeerajarus, Chalida Nakalekha Limjeerajarus, Hiroshi Egusa, Thanaphum Osathanon, Phoonsuk Limraksasin
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Shear stress
Extracellular ATP
Angiogenesis
Endothelial differentiation
Human periodontal ligament stem cells
Online Access:https://doi.org/10.1038/s41598-025-12323-w
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https://doi.org/10.1038/s41598-025-12323-w

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