aPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed ultrasound

aPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed ultrasound

Abstract Early diagnosis of pancreatic ductal adenocarcinoma (PDAC) is challenging because of its depth, which often leads to misdiagnosis during ultrasound examinations. The unique PDAC tumor microenvironment (TME) is characterized by significant fibrous tissue growth, and high interstitial pressur...

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Bibliographic Details
Main Authors: Yi Tang, Qingling Shen, Peng Lin, Zhixin Chen, Denghui Fan, Minling Zhuo, Yajiao Gan, Yixi Su, Qingfu Qian, Liwu Lin, Ensheng Xue, Zhikui Chen
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Nanobiotechnology
Subjects:
Contrast-enhanced ultrasound
Molecular diagnosis
Targeted therapy
Tumor microenvironment
Pancreatic cancer
Online Access:https://doi.org/10.1186/s12951-025-03105-7
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