The Effect of Anti‐Activin Receptor Type IIA and Type IIB Antibody on Muscle, Bone and Blood in Healthy and Osteosarcopenic Mice

The Effect of Anti‐Activin Receptor Type IIA and Type IIB Antibody on Muscle, Bone and Blood in Healthy and Osteosarcopenic Mice

ABSTRACT Background Anti‐Activin Receptor Type IIA and Type IIB antibody (αActRIIA/IIB ab) is a recently developed drug class that targets the activin receptor signalling pathway. Inhibition of receptor ligands (activins, myostatin, growth differentiation factor 11, etc.) can lead to skeletal muscle...

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Bibliographic Details
Main Authors: Frederik Duch Bromer, Andreas Lodberg, Marco Eijken, Christian Brix Folsted Andersen, Mathias Flensted Poulsen, Jesper Skovhus Thomsen, Annemarie Brüel
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
haematopoiesis
activin
bimagrumab
disuse
osteoporosis
sarcopenia
Online Access:https://doi.org/10.1002/jcsm.13718
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https://doi.org/10.1002/jcsm.13718

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