Analysis of intestinal epithelial cell responses to Cryptosporidium highlights the temporal effects of IFN-γ on parasite restriction.

Analysis of intestinal epithelial cell responses to Cryptosporidium highlights the temporal effects of IFN-γ on parasite restriction.

The production of IFN-γ is crucial for control of multiple enteric infections, but its impact on intestinal epithelial cells (IEC) is not well understood. Cryptosporidium parasites exclusively infect epithelial cells and the ability of interferons to activate the transcription factor STAT1 in IEC is...

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Main Authors: Ryan D Pardy, Katelyn A Walzer, Bethan A Wallbank, Jessica H Byerly, Keenan M O'Dea, Ian S Cohn, Breanne E Haskins, Justin L Roncaioli, Eleanor J Smith, Gracyn Y Buenconsejo, Boris Striepen, Christopher A Hunter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-05-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011820&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011820&type=printable

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