Identification of nitric oxide as an endogenous inhibitor of 26S proteasomes in vascular endothelial cells.

The 26S proteasome plays a fundamental role in almost all eukaryotic cells, including vascular endothelial cells. However, it remains largely unknown how proteasome functionality is regulated in the vasculature. Endothelial nitric oxide (NO) synthase (eNOS)-derived NO is known to be essential to mai...

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Bibliographic Details
Main Authors: Hongtao Liu, Shujie Yu, Hua Zhang, Jian Xu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0098486
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