Unveiling the mechanism of amelioration of adjuvant-induced rheumatoid arthritis by Drynaria quercifolia rhizome extract using network pharmacology and gene expression-based studies

Unveiling the mechanism of amelioration of adjuvant-induced rheumatoid arthritis by Drynaria quercifolia rhizome extract using network pharmacology and gene expression-based studies

Abstract Rhizomes of Drynaria quercifolia have long been traditionally used to manage rheumatic pain. However, there is limited research supporting this traditional practice and insufficient evidence demonstrating the molecular mechanisms of action of plant-derived bioactives in rheumatoid arthritis...

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Main Authors: Debabrata Modak, Subhajit Ghosh, Sourav Sarkar, Sudipta K. Roy, Ayan Chakraborty, Arpita Ray, Chirag N. Patel, John J. Georrge, Subarna Thakur, Soumen Bhattacharjee
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Drynaria Quercifolia
Rheumatoid arthritis
Network pharmacology
Inflammation
Cytokine
Molecular docking
Online Access:https://doi.org/10.1038/s41598-025-87461-2
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https://doi.org/10.1038/s41598-025-87461-2

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