Investigating the effectiveness of an intraoperative decision support guided fluid therapy intervention on postoperative outcome of high-risk patients undergoing high-risk abdominal surgery: protocol for an international multicentre stepped-wedge cluster-randomised implementation trial

Investigating the effectiveness of an intraoperative decision support guided fluid therapy intervention on postoperative outcome of high-risk patients undergoing high-risk abdominal surgery: protocol for an international multicentre stepped-wedge cluster-randomised implementation trial

Background: Inappropriate fluid administration can impact patient outcome. Intraoperative advanced haemodynamic monitoring coupled with a treatment protocol based on stroke volume optimisation can help determine the appropriate timing for fluid boluses. Although recommended by several anaesthesia so...

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Main Authors: Sean Coeckelenbergh, Amelie Delaporte, Damien Rousseleau, Jacques De Montblanc, Stephanie Roullet, Joanna Ramadan, Bernard Cholley, Alexandre Stibon, Emmanuel Weiss, Maria-Christina Kassab, Sylvain Diop, Elsa Manzi, Marco Pustetto, Guillaume Porta Bonette, Pierre Gregoire Guinot, Philippe Guerci, Domien Vanhonacker, Francois Martin Carrier, Brenton Alexander, Joseph Rinehart, David Boldt, Tristan Grogan, Maxime Cannesson, Jacques Duranteau, Lamiae Grimaldi, Bruno Pereira, Alexandre Joosten
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:BJA Open
Subjects:
acute kidney injury
complications
fluid therapy
goal directed therapy
haemodynamic monitoring
haemodynamic optimisation
Online Access:http://www.sciencedirect.com/science/article/pii/S2772609625000450
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