PARN Maintains RNA Stability to Regulate Insulin Maturation and GSIS in Pancreatic β Cells

PARN Maintains RNA Stability to Regulate Insulin Maturation and GSIS in Pancreatic β Cells

Abstract Diabetes, a metabolic disorder characterized by hyperglycemia, underscores the importance of normal pancreatic β‐cell development and function in maintaining glucose homeostasis. Poly(A)‐specific ribonuclease (PARN) serves as the principal regulator of messenger RNA (mRNA) stability, yet it...

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Bibliographic Details
Main Authors: Xiaomei Xie, Xuexue Chen, Chaofan Wang, Longjie Sun, Weiru Yu, Zheng Lv, Shuang Tian, Xiaohong Yao, Fengchao Wang, Deqiang Ding, Juan Chen, Jiali Liu
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Advanced Science
Subjects:
β cell
insulin maturation and secretion
RNA binding protein
Online Access:https://doi.org/10.1002/advs.202407774
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https://doi.org/10.1002/advs.202407774

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