Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3beta loop.

Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3beta loop.

Invariant Natural Killer T cells (iNKT) are a versatile lymphocyte subset with important roles in both host defense and immunological tolerance. They express a highly conserved TCR which mediates recognition of the non-polymorphic, lipid-binding molecule CD1d. The structure of human iNKT TCRs is uni...

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Main Authors: Gediminas Matulis, Joseph P Sanderson, Nikolai M Lissin, Maria B Asparuhova, Gopal R Bommineni, Daniel Schümperli, Richard R Schmidt, Peter M Villiger, Bent K Jakobsen, Stephan D Gadola
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1000402&type=printable
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https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1000402&type=printable

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