BWC0977, a broad-spectrum antibacterial clinical candidate to treat multidrug resistant infections

BWC0977, a broad-spectrum antibacterial clinical candidate to treat multidrug resistant infections

Abstract The global crisis of antimicrobial resistance (AMR) necessitates the development of broad-spectrum antibacterial drugs effective against multi-drug resistant (MDR) pathogens. BWC0977, a Novel Bacterial Topoisomerase Inhibitor (NBTI) selectively inhibits bacterial DNA replication via inhibit...

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Main Authors: Shahul Hameed P, Harish Kotakonda, Sreevalli Sharma, Radha Nandishaiah, Nainesh Katagihallimath, Ranga Rao, Claire Sadler, Ian Slater, Michael Morton, Abhijeeth Chandrasekaran, Ed Griffen, Dhanashree Pillai, Sambasiva Reddy, Nagakumar Bharatham, Suryanarayanan Venkatesan, Venugopal Jonnalagadda, Ramesh Jayaraman, Mahesh Nanjundappa, Maitrayee Sharma, Savitha Raveendran, Sreenath Rajagopal, Harikrishna Tumma, Amy Watters, Holly Becker, Jill Lindley, Robert Flamm, Michael Huband, Dan Sahm, Meredith Hackel, Tarun Mathur, Ruwanthi Kolamunnage-Dona, Jennifer Unsworth, Laura Mcentee, Nikki Farrington, Dhanasekaran Manickam, Narayana Chandrashekara, Sivakandan Jayachandiran, Hrushikesava Reddy, Sathya Shanker, Vijay Richard, Teby Thomas, Savitha Nagaraj, Santanu Datta, Vasan Sambandamurthy, Vasanthi Ramachandran, Robert Clay, John Tomayko, Shampa Das, Balasubramanian V
Format: Article
Language:English
Published: Nature Portfolio 2024-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-52557-2
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https://doi.org/10.1038/s41467-024-52557-2

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