Enhanced the Trans‐Cleavage Activity of CRISPR‐Cas12a Using Metal‐Organic Frameworks as Stimulants for Efficient Electrochemical Sensing of Circulating Tumor DNA

Enhanced the Trans‐Cleavage Activity of CRISPR‐Cas12a Using Metal‐Organic Frameworks as Stimulants for Efficient Electrochemical Sensing of Circulating Tumor DNA

Abstract Continued development of clustered regularly interspaced short palindromic repeats (CRISPR)‐powered biosensing system on the electrochemical interface is vital for accurate and timely diagnosis in clinical practice. Herein, an electrochemical biosensor based on manganese metal‐organic frame...

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Bibliographic Details
Main Authors: Shuai Wu, Yincheng Liu, Tianyu Zeng, Tianci Zhou, Yanting Sun, Ying Deng, Juan Zhang, Genxi Li, Yongmei Yin
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Advanced Science
Subjects:
Cas12a/crRNA
circulating tumor DNA
CRISPR‐based diagnostics
electrochemical biosensor
metal‐organic framework
Online Access:https://doi.org/10.1002/advs.202417206
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https://doi.org/10.1002/advs.202417206

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