The role of endolysosomal progranulin and TMEM106B in neurodegenerative diseases

Abstract Although different neurodegenerative diseases are defined by distinct pathological proteins, they share many common features including protein aggregation. Despite this commonality, most current therapeutic approaches in the field, such as anti-aggregate antibodies, are focused on individua...

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Bibliographic Details
Main Authors: Hideyuki Takahashi, Stephen M. Strittmatter
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Molecular Neurodegeneration
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Online Access:https://doi.org/10.1186/s13024-025-00873-6
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