Association of PD-1, LAG-3 and TIM-3 expression on intratumoral CD8 T-cells with response to atezolizumab in a Real-World-Evidence biomarker study for advanced urothelial carcinoma patients

Association of PD-1, LAG-3 and TIM-3 expression on intratumoral CD8 T-cells with response to atezolizumab in a Real-World-Evidence biomarker study for advanced urothelial carcinoma patients

Blockade of the PD-1/PD-L1 pathway is part of the standard treatment for advanced urothelial cancer, but reliable predictive biomarkers have not been identified. Here, we analyze with Multiplexed Quantitative Immunofluorescence the pretreatment tumor microenvironment (TME) of urothelial cancer sampl...

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Main Authors: Carlos E. de Andrea, Marta Abengozar-Muela, José Ángel Arranz, Miguel Angel Climent, Javier Puente, Ángel Vizcay, Ligia Montero de la Fuente, José Miguel Jurado, Teresa Bonfill, Carmen Santander, José Carlos Villa, Eduardo Pujol, Adriana Carolina Rosero, Jenifer Gomez, Eva María Fernández, Carlos Álvarez Fernández, Ignacio Ramirez, Pablo Arnáiz, Álvaro López-Janeiro, Ignacio Melero, Miguel F. Sanmamed, José Luis Pérez-Gracia
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:OncoImmunology
Subjects:
PD-1
LAG-3
TIM-3
CD8 T cell
Advanced urothelial carcinoma
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2025.2538687
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https://www.tandfonline.com/doi/10.1080/2162402X.2025.2538687

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