Repurposing of sericin combined with dactolisib or vitamin D to combat non-small lung cancer cells through computational and biological investigations

Repurposing of sericin combined with dactolisib or vitamin D to combat non-small lung cancer cells through computational and biological investigations

Abstract This study aims to repurpose sericin in combating non-small lung cancer cells (A549 and H460) by combining it with dactolisib or vitamin D to reduce the dose of dactolisib and boost the anticancer effectiveness of dactolisib and vitamin D. Therefore, the binding affinities of individual and...

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Bibliographic Details
Main Authors: Maged W. Helmy, Mariam H. Youssef, Imane Yamari, Alaa Amr, Farouzia I. Moussa, Abeer El Wakil, Samir Chtita, Lamia M. El-Samad, Mohamed A. Hassan
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Sericin
Dactolisib
Vitamin D
Lung cancer
Non-small lung cancer cells
Nuclear factor Kappa B (NF-κB)
Online Access:https://doi.org/10.1038/s41598-024-76947-0
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https://doi.org/10.1038/s41598-024-76947-0

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