Senescence, NK cells, and cancer: navigating the crossroads of aging and disease

Senescence, NK cells, and cancer: navigating the crossroads of aging and disease

Cellular senescence, a state of stable cell cycle arrest, acts as a double-edged sword in cancer biology. In young organisms, it acts as a barrier against tumorigenesis, but in the aging population, it may facilitate tumor growth and metastasis through the senescence-associated secretory phenotype (...

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Bibliographic Details
Main Authors: Marina Gergues, Rafijul Bari, Sharmila Koppisetti, Anna Gosiewska, Lin Kang, Robert J. Hariri
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
cellular senescence
NK cells
adoptive immunotherapy
NK cell therapy
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1565278/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1565278/full

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