Endosialin promotes vascular maturation by inhibiting Cyr61 expression in melanoma metastasis

Endosialin promotes vascular maturation by inhibiting Cyr61 expression in melanoma metastasis

BackgroundExtensive tumor cell metastasis is associated with poor patient prognosis. Tumor endothelial cells demonstrate distinct proangiogenic phenotypes compared to normal endothelial cells, partially mediated by pericyte-derived secreted factors. Endosialin, a pericyte biomarker implicated in vas...

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Main Authors: Tong Lu, Hongtao Song, Zhite Zhao, Xinglin He, Chao Xu, Shaojie Liu, Weijun Qin, Bo Yang, Lijun Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Oncology
Subjects:
Endosialin/CD248/TEM-1
Cyr61/CCN1
melanoma
angiogenesis
tumor metastasis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1528288/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1528288/full

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