Synthetic approaches for novel fused pyrimidine derivatives: Design, structural characterization, antiviral, antitumor, and molecular docking evaluation

Synthetic approaches for novel fused pyrimidine derivatives: Design, structural characterization, antiviral, antitumor, and molecular docking evaluation

The goal of this work was to synthesize new compounds for anticancer evaluation as a trial to obtain new antitumor agents with higher activity and fewer side effects. Therefore, the precursor 2,2'-(1,4-phenylenebis (thiazole-4,2-diyl))bis (3-(dimethylamino)acrylonitrile) (4) was used to synthes...

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Main Authors: Fatmah O. Sefrji, Abdulmajeed F. Alrefaei, Mohammed A. Imam, Gadeer R.S. Ashour, Matokah M. Abualnaja, Roba M.S. Attar, A.A.A. Darwish, Nashwa M. El-Metwaly
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Heliyon
Subjects:
Thiazole
Pyrimidine
Antiviral
Cytotoxicity
Molecular docking
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024169344
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http://www.sciencedirect.com/science/article/pii/S2405844024169344

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