Dioscin from smilax china rhizomes inhibits platelet activation and thrombus formation via up-regulating cyclic nucleotides

Abstract Cardiovascular disease, the leading cause of mortality in the United States, is caused by abnormal platelet accumulation and coagulation. Dioscin has been reported to suppress the growth of tumor-associated cells and trigger apoptosis. However, its mechanism in inhibiting platelet activatio...

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Bibliographic Details
Main Authors: Ga Hee Lee, Jin Pyo Lee, Na Yoon Heo, Chang-Dae Lee, Gyeongchan Kim, Akram Abdul Wahab, Man Hee Rhee, Sanghyun Lee, Dong-Ha Lee
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-09452-7
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