Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a) levels in African Americans.

Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a) levels in African Americans.

Lipoprotein(a) (Lp(a)) is an important causal cardiovascular risk factor, with serum Lp(a) levels predicting atherosclerotic heart disease and genetic determinants of Lp(a) levels showing association with myocardial infarction. Lp(a) levels vary widely between populations, with African-derived popul...

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Main Authors: Rahul C Deo, James G Wilson, Chao Xing, Kim Lawson, W H Linda Kao, David Reich, Arti Tandon, Ermeg Akylbekova, Nick Patterson, Thomas H Mosley, Eric Boerwinkle, Herman A Taylor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0014581&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0014581&type=printable

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