Markers of T cell activation and exhaustion in plasma are associated with persistent symptoms up to 18 months following mild SARS-CoV-2 infection

Markers of T cell activation and exhaustion in plasma are associated with persistent symptoms up to 18 months following mild SARS-CoV-2 infection

BackgroundPersistent symptoms following SARS-CoV-2 is an increasing problem after COVID-19 disease. The pathogenesis of this persistent post Covid-19 Condition (PCC) is, however, largely unknown. We hypothesized that persistent T cell activation and exhaustion play a role in PCC development.MethodsW...

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Main Authors: Thor Ueland, Rebecca Jane Cox, Annika E. Michelsen, Elisabeth Berg Fjelltveit, Kari Otterdal, Tuva Dahl, Fan Zhou, Rebecca Elyanow, Pål Aukrust, Bjørn Blomberg, Bente E. Halvorsen, Nina Langeland
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
post-covid condition
T cell activation and exhaustion
persistent symptoms
long-term follow-up
SARS-CoV-2
mild covid-19 infection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1578208/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1578208/full

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