MRI detection of senescent cells in porcine knee joints with a β-galactosidase responsive Gd-chelate

MRI detection of senescent cells in porcine knee joints with a β-galactosidase responsive Gd-chelate

Abstract Senescent cells promote osteoarthritis progression through the secretion of inflammatory mediators. Preclinical studies have identified senescence-associated beta-galactosidase (β-gal) as a biomarker of senescence, but in vivo detection remains challenging. Here, we evaluated whether a β-ga...

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Main Authors: Kerem Nernekli, Dilyana B. Mangarova, Vidyani Suryadevara, Mohammadjavad Hajipour, Jian-Hong Tang, Jie Wang, Tie Liang, Marek Harris, Tsuyoshi Ueyama, Jennifer K. Lyons, Michael E. Moseley, Raheleh Roudi, Laura Pisani, Ricarda von Krüchten, Ramesh Duwa, Sarah Ying Lu-Liang, Zahra Shokri Varniab, Iryna Vasyliv, Neeladrisingha Das, Masatoshi Murayama, Issei Shinohara, Guillem Pratx, Stuart B. Goodman, Thomas J. Meade, Heike E. Daldrup-Link
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Imaging
Online Access:https://doi.org/10.1038/s44303-025-00078-y
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https://doi.org/10.1038/s44303-025-00078-y

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