Activation of AMP-activated Protein Kinase by Metformin Inhibits Dedifferentiation of Platelet-derived Growth Factor-BB-induced Vascular Smooth Muscle Cells to Improve Arterial Remodeling in Cirrhotic Portal HypertensionSummary

Activation of AMP-activated Protein Kinase by Metformin Inhibits Dedifferentiation of Platelet-derived Growth Factor-BB-induced Vascular Smooth Muscle Cells to Improve Arterial Remodeling in Cirrhotic Portal HypertensionSummary

Background & Aims: Portal hypertension (PHT) is the potentially deadly complication of liver cirrhosis. Intrahepatic vascular resistance and the splanchnic hyperdynamic circulation are 2 principal driving factors contributing to the maintenance and exacerbation of PHT. However, in the advanc...

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Main Authors: Guangbo Wu, Qiang Fan, Min Chen, Guqing Luo, Zhenghao Wu, Jinbo Zhao, Jiayun Lin, Chihao Zhang, Hongjie Li, Xiaoliang Qi, Haizhong Huo, Lei Zheng, Meng Luo
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Arterial Remodeling
Liver Cirrhosis
Phenotypic switching of VSMCs
Portal Hypertension
Splanchnic Hyperdynamic Circulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X25000281
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