Glufosinate constrains synchronous and metachronous metastasis by promoting anti‐tumor macrophages

Glufosinate constrains synchronous and metachronous metastasis by promoting anti‐tumor macrophages

Abstract Glutamine synthetase (GS) generates glutamine from glutamate and controls the release of inflammatory mediators. In macrophages, GS activity, driven by IL10, associates to the acquisition of M2‐like functions. Conditional deletion of GS in macrophages inhibits metastasis by boosting the for...

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Main Authors: Alessio Menga, Marina Serra, Simona Todisco, Carla Riera‐Domingo, Ummi Ammarah, Manuel Ehling, Erika M Palmieri, Maria Antonietta Di Noia, Rosanna Gissi, Maria Favia, Ciro L Pierri, Paolo E Porporato, Alessandra Castegna, Massimiliano Mazzone
Format: Article
Language:English
Published: Springer Nature 2020-09-01
Series:EMBO Molecular Medicine
Subjects:
glufosinate
glutamine synthetase
immunometabolism
macrophages
metastasis
Online Access:https://doi.org/10.15252/emmm.201911210
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https://doi.org/10.15252/emmm.201911210

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