Performance of deep-learning-based approaches to improve polygenic scores

Abstract Polygenic scores, which estimate an individual’s genetic propensity for a disease or trait, have the potential to become part of genomic healthcare. Neural-network based deep-learning has emerged as a method of intense interest to model complex, nonlinear phenomena, which may be adapted to...

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Bibliographic Details
Main Authors: Martin Kelemen, Yu Xu, Tao Jiang, Jing Hua Zhao, Carl A. Anderson, Chris Wallace, Adam Butterworth, Michael Inouye
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60056-1
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